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Updated: 2018-08-29

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This picture might not be suitable for all ages. Minors must not be appPrediabetes and Coronary Heart Disease: Risk Stratification and Primary Prevention.
Prediabetes is the most common comorbidity of patients with coronary artery disease (CAD), and evidence indicates that cardiovascular risk increases with the severity of prediabetes. In this review, we discuss the relationship between prediabetes and CAD and the available evidence to support cardiovascular risk stratification and primary prevention. CAD is a leading cause of morbidity and mortality in patients with prediabetes. The marked increase in CAD and the associated mortality among patients with prediabetes and advanced stage diabetes highlight the imperative to develop strategies for primary prevention of cardiovascular events in this high-risk patient population.Isolation and structure elucidation of oligoribosides obtained from the chemical degradation of ribosomal RNA from Saccharomyces cerevisiae.
The extractability of polyribosylribitol phosphate (polyribosylribitol-phosphate, PRR-P) from Saccharomyces cerevisiae by hot aqueous ammonia is limited. By increasing the concentration of this extractant, polyribosylribitol (PRR), a disaccharide of PRR-P, is released. The structure of PRR has been unambiguously identified on the basis of the following results: (1) The molecular weight of PRR (MWPRR) is equal to the sum of the MW of the monomers, i.e., 515. (2) The homogeneity of MWPRR is confirmed by HPLC analysis and the identity of its main component is established by the characteristic ion-pair HPLC profile. (3) The apical pyranose ring of the sugar residue of PRR is assigned by the NMR shift difference of the proton signals, particularly at the anomeric carbon which is affected by a rapid transformation upon the exchange of deuterated water with protons in the medium and the number of proton signals in the H1–H5 region. (4) Two types of polyribosyl ribitol units are identified by the following properties: (a) Ammonolysis of MWPRR results in the formation of ribitol (RIT) and an isolated alanine. (b) Degradation of MWPR

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